Wagstaff School is where Louise, Gene, and Tina go to school. The school is an old three-story brick building. It was founded in 1889. It first appeared in the pilot episode, "Human Flesh" as a flashback. The school was the sole setting for Work Hard or Die Trying, Girl. The school serves at least grades 3-8 and is presumably a K-8 (or PreK-8) school.
- Throughout the series the name of the school has occasionally been misspelled 'Waggstaff School'.
- The school's mascot is the Wagstaff Whaler.
- In "Gene It On", the school's colors appear to be blue and white with a yellow W. In "Mazel Tina", Tammy appeared wearing a cheerleader uniform with a W on it (indicating Wagstaff), but the colors are white and red.
- The episode description of "Broadcast Wagstaff School News" describes Wagstaff School as "the Belcher children's middle school".